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Canagliflozin is indicated for patients with type 2 diabetes to improve glycemic control as monotherapy or in combination with metformin; a sulfonylurea; metformin and a sulfonylurea; metformin and pioglitazone; or insulin (with or without metformin) when these drugs do not provide adequate glycemic control.

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The idealised diagram shows the fluctuation of (red) and the sugar-lowering hormone insulin (blue) in humans during the course of a day containing three meals.

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Crandall J, Schade D, Ma Y, Fujimoto WY, Barrett-Connor E, Fowler S, gogo-Jack S, Andres R: The influence of age on the effects of lifestyle modification and metformin in prevention of diabetes.

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Insulin deficiency is responsible for all three conditions: the body glucose goes largely unused since most cells are unable to transport glucose into the cell without the presence of insulin; this condition makes the body use stored fat as an alternative source instead of the unavailable glucose for energy, a process that produces acidic ketones, which build up because they require insulin to be broken down.

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