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Canagliflozin is indicated for patients with type 2 diabetes to improve glycemic control as monotherapy or in combination with metformin; a sulfonylurea; metformin and a sulfonylurea; metformin and pioglitazone; or insulin (with or without metformin) when these drugs do not provide adequate glycemic control.
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Contribution of postprandial glucose to excess hyperglycaemia in Asian type 2 diabetic patients using continuous glucose monitoring.
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Efficacy and tolerability of acarbose in Asian patients with type 2 diabetes inadequately controlled with diet and sulfonylureas.
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The idealised diagram shows the fluctuation of (red) and the sugar-lowering hormone insulin (blue) in humans during the course of a day containing three meals.
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Several therapeutic classes of non-insulin hypoglycemic agents are commonly used to manage hyperglycemia in type-2 diabetes ().
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Crandall J, Schade D, Ma Y, Fujimoto WY, Barrett-Connor E, Fowler S, gogo-Jack S, Andres R: The influence of age on the effects of lifestyle modification and metformin in prevention of diabetes.
Harvard School of Public Health (C.
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Insulin deficiency is responsible for all three conditions: the body glucose goes largely unused since most cells are unable to transport glucose into the cell without the presence of insulin; this condition makes the body use stored fat as an alternative source instead of the unavailable glucose for energy, a process that produces acidic ketones, which build up because they require insulin to be broken down.
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In response, the VHA Women's Health Service requested an evidence map to (1) identify effective interventions in women, (2) better understand sex differences in intervention effects for high-impact medical conditions, and (3) identify gaps in evidence about the efficacy of interventions in women.
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European Association for the Study of Diabetes (EASD) described research which may point to why metformin is so effective.
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This drop in patient numbers is unavoidable because of the nature of post hoc analyses but may introduce bias into the results, particularly as East Asians were the largest group included in the analyses.
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The new Dutch type 2 diabetes management guideline specifically advises gliclazide as the preferred second treatment option and not SUs as a group.
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Possible explanations relate to differences between RCTs for regulatory approval and post-marketing non-interventional observational studies.
Moreover, there is a good inverse correlation between adiponectin and HbA 1c% in blood of the patients treated with Guava Leaf Tea or acarbose.
The primary endpoint was change in HbA1c from baseline to 48 weeks.
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Evaluating Cardiovascular Safety of Novel Therapeutic Agents for the Treatment of Type 2 Diabetes Mellitus.
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The results were analysed according to the clinical and laboratory methods, including the study of the lipid peroxidation (LP) with the help ofmalonil dialdehyd (MDA) level in serum.
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