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Efficacy and safety of immediate angioplasty versus ischemia-guided management after thrombolysis in acute myocardial infarction in areas with very long transfer distances results of the NORDISTEMI (NORwegian study on DIstrict treatment of ST-elevation myocardial infarction).
Contribution of hepatic cytochrome P450 3A4 metabolic activity to the phenomenon of clopidogrel resistance.
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Cangrelor: A Review in Percutaneous Coronary Intervention.
It may also be performed to prevent and in women with a strong genetic risk.
Medical Management of Carotid Artery Disease.
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Prior aspirin users with acute non-ST-elevation coronary syndromes are at increased risk of cardiac events and benefit from enoxaparin.
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One limitation to calculating adherence using this method is that it assumes that the number of pills absent were actually taken by the patients.
This section may also include your literature review, with details of gaps in current understanding of your topic, and how existing literature has informed your methodology.
For patients with ST-elevation myocardial infarction (STEMI), Clopidogrel has been shown to reduce the rate of death from any cause and the rate of a combined endpoint of death, re-infarction, or stroke.
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Our study demonstrates the benefit of adding clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with ST-segment elevation.
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FACTORS ASSOCIATED WITH ASPIRIN RESISTANCE IN PATIENTS PREMEDICATED WITH ASPIRIN AND CLOPIDOGREL FOR ENDOVASCULAR NEUROSURGERY.
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The clinically important adverse reactions observed in trials comparing clopidogrel plus aspirin to placebo plus aspirin and trials comparing clopidogrel alone to aspirin alone are discussed below.
Gene Expression Signatures and the Spectrum of Coronary Artery Disease.
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We undertook a randomized, double-blind, placebo-controlled trial comparing clopidogrel with placebo in patients who presented with acute coronary syndromes without ST-segment elevation.
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To determine the risks, the study team performed an analysis of a populationbased longitudinal cohort study with data linkage to the Australian national death index, and to national databases of nonhospital episodes of medical care and prescription medications dispensed between July 1, 2002, and August 31, 2013.
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Effect of Glycemic Control on Response to Antiplatelet Therapy in Patients With Diabetes Mellitus and ST-Segment Elevation Myocardial Infarction.
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Influence of Genetic Polymorphisms on Clopidogrel Response and Clinical Outcomes in Patients with Acute Ischemic Stroke CYP2C19 Genotype on Clopidogrel Response.
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Conclusion: Almost half of subjects receiving clopidogrel plus aspirin without omeprazole had significant short-term gastroduodenal mucosal injury.
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Long-acting CCBs and nitrates are recommended in patients with coronary artery spasm.
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If during the trial a patient experienced more than one non-fatal event of the same type (for example, two myocardial infarctions) or more than one pathological type of stroke (for example, a haemorrhagic stroke and an ischaemic stroke), only the first was to be recorded.
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Overall, these benefits were offset by an absolute excess of 23 major extracranial bleeds per 1000 patients treated, although fatal bleeding was rare.
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The platelet count was immediately repeated taking blood samples with citrate as the anticoagulant, in order to rule out EDTA-dependent pseudothrombocytopenia.
Dual antiplatelet therapy with the combination of clopidogrel and aspirin has recently also been evaluated in patients with STEMI.
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ST-elevation myocardial infarction first, and only if there was a statistically significant difference between the treatment groups was this end point analyzed in the overall cohort.
As your body adjusts to the medicine during treatment these side effects may go away.
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In contrast, among the relatively few patients with STEMI in TRITON-TIMI 38 who underwent CABG during the 15-month course of the study, rates of TIMI major or minor bleeding after CABG were significantly higher with prasugrel than with clopidogrel (21.
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Use of this medication before or after these procedures has rarely caused major bleeding or in or around the spine.
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These strategies have not been adopted widely because of their limited performance characteristics and are not recommended for routine use.
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